BAM 15

Name: BAM 15
Brand: Tocris Bioscience
SKU: 5737

Tocris Bioscience, part of Bio-Techne | Catalog # 5737

Citations (17)

COA / SDS

Mitochondrial protonophore uncoupler

Key Product Details

Description:	Mitochondrial protonophore uncoupler
Chemical Name:	N⁵,N⁶-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Purity:	≥98% (HPLC)
Molecular Weight:	340.29

View Full Technical Details for BAM 15

Technical Data
Citations

Biological Activity for BAM 15

BAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC₅₀ = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.

Compound Libraries for BAM 15

BAM 15 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAM 15

M. Wt	340.29
Formula	C₁₆H₁₀F₂N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	210302-17-3
PubChem ID	565708
InChi Key	OEGJBRZAJRPPHL-UHFFFAOYSA-N
Smiles	FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAM 15

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.03	100

Preparing Stock Solutions for BAM 15

The following data is based on the product molecular weight 340.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.39 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Reconstitution Calculator

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References for BAM 15

References are publications that support the biological activity of the product.

Kenwood Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 2013 PMID: 24634817
Axelrod BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol.Med. 2020 PMID: 32519812
Kenwood Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 2015 PMID: 26119501