BAM 15
Tocris Bioscience, part of Bio-Techne | Catalog # 5737
Mitochondrial protonophore uncoupler
Key Product Details
Description
Mitochondrial protonophore uncoupler
Product Description
BAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.Product Specifications
Molecular Weight
340.29
Formula
C16H10F2N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
CAS Number
210302-17-3
PubChem ID
565708
InChI Key
OEGJBRZAJRPPHL-UHFFFAOYSA-N
SMILES
FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.03 | 100 |
Preparing Stock Solutions
for BAM 15
The following data is based on the product molecular weight 340.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.69 mL | 29.39 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kenwood Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 2013 PMID: 24634817
- Axelrod BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol.Med. 2020 PMID: 32519812
- Kenwood Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 2015 PMID: 26119501
Product Specific Notices for BAM 15
For research use only
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