BAG 956

Tocris Bioscience, part of Bio-Techne | Catalog # 3606

Dual PI 3-kinase and PDPK1 (PDK1) inhibitor
Discontinued Product
3606 has been discontinued. View all PI 3-Kinase Inhibitors products.

Key Product Details

Description

Dual PI 3-kinase and PDPK1 (PDK1) inhibitor

View all PI 3-Kinase Inhibitors »

Product Description

BAG 956 is a dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.

Product Specifications

Molecular Weight

427.50

Formula

C28H21N5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile

CAS Number

853910-02-8

PubChem ID

24882589

InChI Key

GVPAGJWVBUZHNQ-UHFFFAOYSA-N

SMILES

CC3=NC1=C(N3C4=CC=C(C(C)(C#N)C)C=C4)C2=C(C=CC(C#CC5=CN=CC=C5)=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.1 40
Ethanol 8.55 20

Preparing Stock Solutions for BAG 956

The following data is based on the product molecular weight 427.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 5.85 mL 29.24 mL 58.48 mL
2 mM 1.17 mL 5.85 mL 11.70 mL
4 mM 0.58 mL 2.92 mL 5.85 mL
20 mM 0.12 mL 0.58 mL 1.17 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for BAG 956

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BAG 956

For research use only

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