Azurin p28 peptide

Name: Azurin p28 peptide
Brand: Tocris Bioscience
SKU: 7662

Tocris Bioscience, part of Bio-Techne | Catalog # 7662

COA / SDS

Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53

Discontinued Product

7662 has been discontinued. View all p53 products.

Key Product Details

Description:	Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53
Purity:	≥95% (HPLC)
Molecular Weight:	2914.2

View Full Technical Details for Azurin p28 peptide

Technical Data
Citations

Biological Activity for Azurin p28 peptide

Azurin p28 peptide is a 28 amino acid fragment of azurin (amino acids 50-77). The peptide is preferentially taken up by human breast cancer cell lines via caveolin-mediated endocytosis. Azurin p28 peptide binds wild-type and mutant p53 protein and inhibits E3 ligase COP1-mediated ubiquitination of p53 by >80%, resulting in decreased proteasomal degradation of p53. It induces cell cycle arrest in the G₂/M phase leading to apoptosis. Azurin p28 peptide exhibits antiproliferative effects in human breast cancer cells in vitro and in vivo.

Technical Data for Azurin p28 peptide

M. Wt	2914.2
Formula	C₁₂₂H₁₉₇N₃₁O₄₇S₂
Single Letter Sequence	LSTAADMQGVVTDGMASGLDKDYLKPDD
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	897026-25-4
PubChem ID	53363312
InChi Key	RFGPECAMUVWTJN-AWHPYGDNSA-N
Smiles	O=C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Azurin p28 peptide

References are publications that support the biological activity of the product.

Yamada p28, a first in class peptide inhibitor of cop1 binding to p53. Br.J.Cancer 2013 PMID: 23736031
Yamada A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol.Cancer Ther. 2009 PMID: 19808975
Yaghoubi p28 bacterial peptide, as an anticancer agent. Front.Oncol. 2020 PMID: 32850408

Azurin p28 peptide

Tocris Bioscience, part of Bio-Techne | Catalog # 7662

Key Product Details

Biological Activity for Azurin p28 peptide

Technical Data for Azurin p28 peptide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Azurin p28 peptide

Product Documents for Azurin p28 peptide

COA

Certificate of Analysis

SDS

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