AZD 7762 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5199

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing
Discontinued Product
5199 has been discontinued. View all Checkpoint Kinase Inhibitors products.

Key Product Details

Description

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

View all Checkpoint Kinase Inhibitors »

Product Description

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC50 vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo. Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 μM).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications

Molecular Weight

398.88

Formula

C17H19FN4O2S.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride

CAS Number

1246094-78-9

PubChem ID

56972142

InChI Key

WFZBLOIXZRZEDG-YDALLXLXSA-N

SMILES

FC1=CC=CC(C2=CC(NC(N)=O)=C(C(N[C@@H]3CNCCC3)=O)S2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.89 100
DMSO 39.89 100

Preparing Stock Solutions for AZD 7762 hydrochloride

The following data is based on the product molecular weight 398.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.54 mL 25.07 mL
5 mM 0.50 mL 2.51 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Product Documents for AZD 7762 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZD 7762 hydrochloride

For research use only

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