AZD 6482
Tocris Bioscience, part of Bio-Techne | Catalog # 4839
Potent and selective PI 3-Kβ inhibitor
Key Product Details
Description
Potent and selective PI 3-Kβ inhibitor
Product Description
AZD 6482 is a potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
408.45
Formula
C22H24N4O4
Storage
Store at -20°C
Purity
≥98%
Chemical Name
(-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
CAS Number
1173900-33-8
PubChem ID
44137675
InChI Key
IRTDIKMSKMREGO-OAHLLOKOSA-N
SMILES
OC(C1=C(N[C@@H](C2=CC(C)=CN3C2=NC(N4CCOCC4)=CC3=O)C)C=CC=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 4.08 | 10 | |
| DMSO | 40.84 | 100 |
Preparing Stock Solutions
for AZD 6482
The following data is based on the product molecular weight 408.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.90 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ni Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 PMID: 22588880
- Nylander Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and Ins sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 2012 PMID: 22906130
Product Specific Notices for AZD 6482
For research use only
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