AZD 5582 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5141
Dimeric Smac mimetic; potent IAP inhibitor
Key Product Details
Description
Dimeric Smac mimetic; potent IAP inhibitor
Product Description
AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.Licensing Information
Sold with the permission of AstraZeneca UK LtdProduct Specifications
Molecular Weight
1088.21
Formula
C58H78N8O8.2HCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
CAS Number
1883545-51-4
PubChem ID
90489014
InChI Key
DAILKFFMJFAUCE-GXSVUDMFSA-N
SMILES
CN[C@@H](C)C(N[C@@H]([C@H]1CCCCC1)C(N2[C@H]([C@](N[C@H]3C(C=CC=C5)=C5C[C@H]3OCC#CC#CCO[C@@H]4CC8=C(C=CC=C8)[C@@H]4N[C@@]([C@H](CCC7)N7C([C@H]([C@H]6CCCCC6)NC([C@H](C)NC)=O)=O)=O)=O)CCC2)=O)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 108.82 | 100 | |
| DMSO | 108.82 | 100 |
Preparing Stock Solutions
for AZD 5582 dihydrochloride
The following data is based on the product molecular weight 1088.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.92 mL | 4.59 mL | 9.19 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.92 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hennessy Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J.Med.Chem. 2013 PMID: 24320998
Product Specific Notices for AZD 5582 dihydrochloride
For research use only
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