AZ PFKFB3 26

Name: AZ PFKFB3 26
Brand: Tocris Bioscience
SKU: 5675

Tocris Bioscience, part of Bio-Techne | Catalog # 5675

COA / SDS

Potent and selective PFKFB3 inhibitor

Key Product Details

Description:	Potent and selective PFKFB3 inhibitor
Chemical Name:	(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	402.49

View Full Technical Details for AZ PFKFB3 26

Technical Data
Citations

Biological Activity for AZ PFKFB3 26

AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor (IC₅₀ = 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC₅₀ values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC₅₀ = 0.343 μM). Exhibits no significant inhibition of other kinases.

Compound Libraries for AZ PFKFB3 26

AZ PFKFB3 26 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZ PFKFB3 26

M. Wt	402.49
Formula	C₂₄H₂₆N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1704740-52-2
PubChem ID	118735769
InChi Key	OOGHGWKBJXQNEJ-QFIPXVFZSA-N
Smiles	N#CC1=CN(CC(C)C)C2=C1C=C(OC3=CC=C(NC([C@H]4NCCC4)=O)C=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ PFKFB3 26

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.25	100
	ethanol	40.25	100

Preparing Stock Solutions for AZ PFKFB3 26

The following data is based on the product molecular weight 402.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.42 mL	24.85 mL
5 mM	0.50 mL	2.48 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for AZ PFKFB3 26

References are publications that support the biological activity of the product.

Boyd Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 2015 PMID: 25849762