AZ PFKFB3 26
Tocris Bioscience, part of Bio-Techne | Catalog # 5675
Potent and selective PFKFB3 inhibitor
Product Description
AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor (IC50 = 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50 values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.343 μM). Exhibits no significant inhibition of other kinases.Product Specifications
Molecular Weight
402.49
Formula
C24H26N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
CAS Number
1704740-52-2
PubChem ID
118735769
InChI Key
OOGHGWKBJXQNEJ-QFIPXVFZSA-N
SMILES
N#CC1=CN(CC(C)C)C2=C1C=C(OC3=CC=C(NC([C@H]4NCCC4)=O)C=C3)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.25 | 100 | |
| Ethanol | 40.25 | 100 |
Preparing Stock Solutions
for AZ PFKFB3 26
The following data is based on the product molecular weight 402.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.42 mL | 24.85 mL |
| 5 mM | 0.50 mL | 2.48 mL | 4.97 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Boyd Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 2015 PMID: 25849762
Product Specific Notices for AZ PFKFB3 26
For research use only
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