AZ Dyrk1B 33

Name: AZ Dyrk1B 33
Brand: Tocris Bioscience
SKU: 5632

Tocris Bioscience, part of Bio-Techne | Catalog # 5632

Citations (1)

COA / SDS

Potent and selective Dyrk1B kinase inhibitor

Key Product Details

Description:	Potent and selective Dyrk1B kinase inhibitor
Chemical Name:	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
Purity:	≥98% (HPLC)
Molecular Weight:	300.36

View Full Technical Details for AZ Dyrk1B 33

Technical Data
Citations

Biological Activity for AZ Dyrk1B 33

AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC₅₀ = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC₅₀ = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).

Compound Libraries for AZ Dyrk1B 33

AZ Dyrk1B 33 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ Dyrk1B 33

M. Wt	300.36
Formula	C₁₉H₁₆N₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1679330-37-0
PubChem ID	118735338
InChi Key	CZCUSHJQJWKYTD-UHFFFAOYSA-N
Smiles	CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=CN=CC=C42)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ Dyrk1B 33

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	30.04	100
	DMSO	30.04	100

Preparing Stock Solutions for AZ Dyrk1B 33

The following data is based on the product molecular weight 300.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.33 mL	16.65 mL	33.29 mL
5 mM	0.67 mL	3.33 mL	6.66 mL
10 mM	0.33 mL	1.66 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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References for AZ Dyrk1B 33

References are publications that support the biological activity of the product.

Kettle Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 2015 PMID: 25738750