AZ'9567
Tocris Bioscience, part of Bio-Techne | Catalog # 8897
Potent MAT2a (methionine adenosyltransferase 2a) inhibitor
Key Product Details
Description
Potent MAT2a (methionine adenosyltransferase 2a) inhibitor
Product Description
AZ'9567 is a potent MAT2a (methionine adenosyltransferase 2a) inhibitor (IC50 = 1.3 nM). AZ'9567 shows strong antiproliferative effect on methylthioadenosine phosphorylase (MTAP) null lymphoma, lung, and pancreatic cancer cell lines and in vivo in MTAP KO HCT116 xenograft mouse model (20 mg/kg twice a day). AZ'9567 is orally bioavailable.Product Specifications
Molecular Weight
447.45
Formula
C24H19F2N5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-Cyclopropyl-4-[4-(difluoromethoxy)phenyl]-1,4-dihydro-6-(2-methyl-2H-indazol-5-yl)-5H-pyrazolo[4,3-b]pyridin-5-one
CAS Number
3056570-19-2
PubChem ID
170995115
InChI Key
QEASMQZYZCGOSA-UHFFFAOYSA-N
SMILES
O=C1C(C2=CC3=CN(C)N=C3C=C2)=CC4=C(N1C5=CC=C(C=C5)OC(F)F)C(C6CC6)=NN4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.74 | 100 | |
| Ethanol | 4.47 | 10 |
Preparing Stock Solutions
for AZ'9567
The following data is based on the product molecular weight 447.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.17 mL | 22.35 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.47 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Atkinson Development of a series of pyrrolopyridone MAT2A inhibitors. J.Med.Chem. 2024 PMID: 38466661
Product Specific Notices for AZ'9567
For research use only
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