AZ 6102
Tocris Bioscience, part of Bio-Techne | Catalog # 5775
Potent TNKS1/2 inhibitor
Product Description
AZ 6102 is a potent TNKS2 and TNKS1 inhibitor (IC50 values are 1 and 3 nM, respectively). Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6. Inhibits Wnt signaling in DLD-1 cells (IC50 = 5 nM). Exhibits moderate oral bioavailability.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ6102 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
428.53
Formula
C25H28N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one
CAS Number
1645286-75-4
PubChem ID
91663328
InChI Key
WCPTUQOMNJBIET-CALCHBBNSA-N
SMILES
CC1=CC(N2C[C@H](C)N[C@H](C)C2)=NC=C1C3=CC=C(C(N4)=NC5=C(C=CN5C)C4=O)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.43 | 50 |
Preparing Stock Solutions
for AZ 6102
The following data is based on the product molecular weight 428.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.67 mL | 23.34 mL | 46.67 mL |
| 2.5 mM | 0.93 mL | 4.67 mL | 9.33 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 25 mM | 0.09 mL | 0.47 mL | 0.93 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Johannes Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. ACS Med.Chem.Lett. 2015 PMID: 25815142
Product Specific Notices for AZ 6102
For research use only
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