AY-NH2
Tocris Bioscience, part of Bio-Techne | Catalog # 1487
Selective PAR4 agonist
Key Product Details
Description
Selective PAR4 agonist
Alternative Names
AYPGKF-NH2
Product Description
AY-NH2 is a selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.Product Specifications
Molecular Weight
680.80
Formula
C34H48N8O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
352017-71-1
PubChem ID
9987061
InChI Key
BBAOHIALRKLBRD-OZDPOCAXSA-N
SMILES
[H]N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Hollenberg and Saifeddine Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 2001 PMID: 11405248
- Hollenburg Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 2004 PMID: 15451771
- Faruqi Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 2000 PMID: 10779527
Product Specific Notices for AY-NH2
For research use only
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