AX 15836
Tocris Bioscience, part of Bio-Techne | Catalog # 5843
Potent and selective ERK5 inhibitor
Product Description
AX 15836 is a potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AX15836 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
648.78
Formula
C32H40N8O5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
CAS Number
2035509-96-5
PubChem ID
122705989
InChI Key
HTFNVAVTYILUCF-UHFFFAOYSA-N
SMILES
CCOC1=C(NC2=NC=C3N(C)C(=O)C4=C(C=CC=C4)N(C3=N2)S(C)(=O)=O)C=CC(=C1)C(=O)N1CCC(CC1)N1CCN(C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 64.88 | 100 | |
| DMSO | 64.88 | 100 |
Preparing Stock Solutions
for AX 15836
The following data is based on the product molecular weight 648.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.54 mL | 7.71 mL | 15.41 mL |
| 5 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.54 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gilbert Vomocytosis of live pathogens from macrophages is regulated by the atypcial MAP kinase ERK5. Sci.Adv. 2017 PMID: 28835924
- Lin ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 27679845
Product Specific Notices for AX 15836
For research use only
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