Autocamtide-2-related inhibitory peptide

Name: Autocamtide-2-related inhibitory peptide
Brand: Tocris Bioscience
SKU: 1688

Tocris Bioscience, part of Bio-Techne | Catalog # 1688

Citations (16)

COA / SDS

Selective CaM kinase II inhibitor

Key Product Details

Description:	Selective CaM kinase II inhibitor
Alternative Names:	AIP
Purity:	≥95% (HPLC)
Molecular Weight:	1497.76

View Full Technical Details for Autocamtide-2-related inhibitory peptide

Technical Data
Citations

Biological Activity for Autocamtide-2-related inhibitory peptide

Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC₅₀ = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC₅₀ > 10 μM).

Cell permeable derivative also available.

Technical Data for Autocamtide-2-related inhibitory peptide

M. Wt	1497.76
Formula	C₆₄H₁₁₆N₂₂O₁₉
Single Letter Sequence	KKALRRQEAVDAL
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	167114-91-2
PubChem ID	25031982
InChi Key	USSJDGBHUQEJJG-HKDQSZHBSA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Autocamtide-2-related inhibitory peptide

Solubility

Soluble to 1mg/ml in water

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References for Autocamtide-2-related inhibitory peptide

References are publications that support the biological activity of the product.

Ishida and Fujisawa Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 1995 PMID: 7836445
Takasawa Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca²⁺ mobilization. J.Biol.Chem. 1995 PMID: 8530441
Ishida A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 1995 PMID: 7626114