ATC 0175 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3346
MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
Discontinued Product
3346 has been discontinued.
View all Melanin-concentrating Hormone Receptor Antagonists products.
Key Product Details
Description
MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
Product Description
ATC 0175 hydrochloride is a potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT2B and 5-HT1A receptors (IC50 values are 9.66 and 16.9 nM respectively).Product Specifications
Molecular Weight
461.94
Formula
C23H25F2N5O.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride
CAS Number
510733-97-8
PubChem ID
9934032
InChI Key
HUUPKFUYSQNNLO-UHFFFAOYSA-N
SMILES
O=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.62 | 10 | |
| Ethanol | 11.55 | 25 |
Preparing Stock Solutions
for ATC 0175 hydrochloride
The following data is based on the product molecular weight 461.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 8.66 mL | 43.30 mL | 86.59 mL |
| 1.25 mM | 1.73 mL | 8.66 mL | 17.32 mL |
| 2.5 mM | 0.87 mL | 4.33 mL | 8.66 mL |
| 12.5 mM | 0.17 mL | 0.87 mL | 1.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chaki ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 PMID: 16614734
- Chaki Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 2005 PMID: 15677346
Product Specific Notices for ATC 0175 hydrochloride
For research use only
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