aTAG 4531
Tocris Bioscience, part of Bio-Techne | Catalog # 6971
Degrader of MTH1 fusion proteins for use within the aTAG system
Key Product Details
Description
Degrader of MTH1 fusion proteins for use within the aTAG system
Alternative Names
CFT 4531
Product Description
aTAG 4531 is a degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat. No. 0652). Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications.Mouse DMPK properties are provided in the supplementary file (see below).
MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in. See protocol for more information.
Licensing Information
Sold under license from C4 TherapeuticsSupplementary Information
Mouse DMPK properties are provided in the accompanying supplementary file.Product Specifications
Molecular Weight
867.85
Formula
C46H39F2N9O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
CAS Number
2412985-00-1
InChI Key
BNHRIFMLKOQTPS-UHFFFAOYNA-N
SMILES
O=C(NC1CC1)C2=C(C3=C(N=C2)C=C(F)C(C4=CC(F)=C(C=C4)C(NCCCCN5N=NC(COC6=C(C7=CC=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=C5)=O)=C3)NC9=CC=CC=C9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 86.78 | 100 |
Preparing Stock Solutions
for aTAG 4531
The following data is based on the product molecular weight 867.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.52 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for aTAG 4531
For research use only
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