aTAG 2139
Tocris Bioscience, part of Bio-Techne | Catalog # 6970
Degrader of MTH1 fusion proteins for use within the aTAG system
Key Product Details
Description
Degrader of MTH1 fusion proteins for use within the aTAG system
Alternative Names
CFT 2139
Product Description
aTAG 2139 is a degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat. No. 0652). Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%). Cell-permeable. Suitable for in vitro and in vivo applications.Negative control aTAG 2139-NEG (Cat. No. 7575) also available.
Mouse DMPK properties are provided in the supplementary file (see below).
MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in. See protocol for more information.
Licensing Information
Sold under exclusive license from C4 TherapeuticsSupplementary Information
Mouse DMPK properties are provided in the accompanying supplementary file.Product Specifications
Molecular Weight
782.81
Formula
C42H38N8O8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
CAS Number
2387510-81-6
InChI Key
IKLCDLVLZPLJRR-UHFFFAOYSA-N
SMILES
O=C(CCC1N2C(C3=C(C(OCC(NCCCCNC(C4=CC=C(C5=CC=C(N=CC(C(NC)=O)=C6NC7=CC=CC=C7)C6=C5)C=N4)=O)=O)=CC=C3)C2=O)=O)NC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.14 | 50 |
Preparing Stock Solutions
for aTAG 2139
The following data is based on the product molecular weight 782.81
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.55 mL | 12.77 mL | 25.55 mL |
| 2.5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 5 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 25 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Veits Development of an AchillesTAG degradation system and its application to control CAR-T activity. Curr.Res.Chem.Biol.
Product Specific Notices for aTAG 2139
For research use only
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