AS 1949490

Name: AS 1949490
Brand: Tocris Bioscience
SKU: 3718

Catalog # 3718 | Tocris Bioscience a Bio-Techne Brand

Citations (9)

COA / SDS

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

Key Product Details

Description:	SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor
Chemical Name:	3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	371.88

View Full Technical Details for AS 1949490

Technical Data
Citations (9) / Reviews

Biological Activity for AS 1949490

AS 1949490 is a selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC₅₀ values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Also promotes increased BDNF mRNA levels in cultured cortical neurons and has memory enhancing and antidepressant effects in vivo.

Compound Libraries for AS 1949490

AS 1949490 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AS 1949490

M. Wt	371.88
Formula	C₂₀H₁₈ClNO₂S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1203680-76-5
PubChem ID	44473434
InChi Key	RFZPGNRLOKVZJY-AWEZNQCLSA-N
Smiles	ClC(C=C2)=CC=C2COC1=C(C(N[C@@H](C)C3=CC=CC=C3)=O)SC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AS 1949490

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.19	100
	ethanol	37.19	100

Preparing Stock Solutions for AS 1949490

The following data is based on the product molecular weight 371.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AS 1949490

References are publications that support the biological activity of the product.

Tsuneki AS1949490, an inhibitor of 5'-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons. Eur.J.Pharmacol. 2019 PMID: 30753865
Suwa Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur.J.Pharmacol. 2010 PMID: 20558154
Suwa Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br.J.Pharmcol. 2009 PMID: 19694723

Citations for AS 1949490 (9)

Showing 1 - 9 of 9 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for AS 1949490 include:

Stéphane et al. (2023) Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment. iScience. 26:106071
PMID: 36818285
Justyna et al. (2022) Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules. 12
PMID: 35454152
Cheng-Han et al. (2021) PI(3,4)P2-mediated membrane tubulation promotes integrin trafficking and invasive cell migration. Proc Natl Acad Sci U S A. 118
PMID: 33947811
Polianskyte-Prause et al. (2019) MetF. increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. FASEB J. 33:2858
PMID: 30321069
Hak et al. (2018) FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nat Cell Biol. 20:1023
PMID: 30061681
Ghosh et al. (2018) Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells. J Cell Sci. 131
PMID: 30012834
Sérgio B et al. (2017) Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects. Hum Mutat. 38:1731-1739
PMID: 28869677
Hughes et al. (2015) PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Front Neurosci. 26:3867
PMID: 26337385
Chang et al. (2014) Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Mol Biol Cell. 62:296
PMID: 24148856

There are no citations that match your criteria.