AS 1949490

Name: AS 1949490
Brand: Tocris Bioscience
SKU: 3718

Tocris Bioscience, part of Bio-Techne | Catalog # 3718

Citations (22)

COA / SDS

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

Key Product Details

Description:	SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor
Chemical Name:	3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	371.88

View Full Technical Details for AS 1949490

Technical Data
Citations

Biological Activity for AS 1949490

AS 1949490 is a selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC₅₀ values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Also promotes increased BDNF mRNA levels in cultured cortical neurons and has memory enhancing and antidepressant effects in vivo.

Compound Libraries for AS 1949490

AS 1949490 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AS 1949490

M. Wt	371.88
Formula	C₂₀H₁₈ClNO₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1203680-76-5
PubChem ID	44473434
InChi Key	RFZPGNRLOKVZJY-AWEZNQCLSA-N
Smiles	ClC(C=C2)=CC=C2COC1=C(C(N[C@@H](C)C3=CC=CC=C3)=O)SC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AS 1949490

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.19	100
	ethanol	37.19	100

Preparing Stock Solutions for AS 1949490

The following data is based on the product molecular weight 371.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for AS 1949490

References are publications that support the biological activity of the product.

Suwa Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br.J.Pharmcol. 2009 PMID: 19694723
Tsuneki AS1949490, an inhibitor of 5'-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons. Eur.J.Pharmacol. 2019 PMID: 30753865
Suwa Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur.J.Pharmacol. 2010 PMID: 20558154