AS 1842856

Name: AS 1842856
Brand: Tocris Bioscience
SKU: 4265

Tocris Bioscience, part of Bio-Techne | Catalog # 4265

Citations (3)

COA / SDS

Potent and selective Foxo1 inhibitor; orally bioavailable

Key Product Details

Description:	Potent and selective Foxo1 inhibitor; orally bioavailable
Chemical Name:	5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	347.39

View Full Technical Details for AS 1842856

Technical Data
Citations

Biological Activity for AS 1842856

AS 1842856 is a potent and selective Foxo1 inhibitor (IC₅₀ values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis both in vitro and in vivo. Attenuates fasting plasma glucose level in diabetic db/db mice. Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression. Also inhibits STAT3 signaling in NSCLC. Orally bioavailable.

Technical Data for AS 1842856

M. Wt	347.39
Formula	C₁₈H₂₂FN₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	836620-48-5
PubChem ID	72193864
InChi Key	MOMCHYGXXYBDCD-UHFFFAOYSA-N
Smiles	CCN1C=C(C(C2=C(C(F)=C(C=C12)NC3CCCCC3)N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AS 1842856

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.74	5 with gentle warming

Preparing Stock Solutions for AS 1842856

The following data is based on the product molecular weight 347.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	57.57 mL	287.86 mL	575.72 mL
0.25 mM	11.51 mL	57.57 mL	115.14 mL
0.5 mM	5.76 mL	28.79 mL	57.57 mL
2.5 mM	1.15 mL	5.76 mL	11.51 mL

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References for AS 1842856

References are publications that support the biological activity of the product.

Liu FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes. Cell Cycle 2016 PMID: 27260854
Galley Antagonism of forkhead box subclass O transcription factors elicits loss of soluble guanylyl cyclase expression. Mol.Pharmacol. 2019 PMID: 30988014
Nagashima Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol.Pharmacol. 2010 PMID: 20736318