AS 1517499
Tocris Bioscience, part of Bio-Techne | Catalog # 7636
STAT6 inhibitor
Product Description
AS 1517499 is a potent STAT6 inhibitor (IC50 = 21 nM). In vitro, it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.Product Specifications
Molecular Weight
397.86
Formula
C20H20ClN5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[2-(3-Chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide
CAS Number
919486-40-1
PubChem ID
10340781
InChI Key
OZRMEKAUZBKTTC-UHFFFAOYSA-N
SMILES
O=C(N)C1=CN=C(N=C1NCC=2C=CC=CC2)NCCC3=CC=C(O)C(Cl)=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.89 | 50 | |
| Ethanol | 3.98 | 10 |
Preparing Stock Solutions
for AS 1517499
The following data is based on the product molecular weight 397.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.03 mL | 25.13 mL | 50.27 mL |
| 2.5 mM | 1.01 mL | 5.03 mL | 10.05 mL |
| 5 mM | 0.50 mL | 2.51 mL | 5.03 mL |
| 25 mM | 0.10 mL | 0.50 mL | 1.01 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nagashima Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine- 5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg.Med.Chem. 2008 PMID: 18534856
- Nagashima Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg.Med.Chem. 2007 PMID: 17071093
- Chiba A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am.J.Respir.Cell Mol.Biol. 2009 PMID: 19202006
Product Specific Notices for AS 1517499
For research use only
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