ARN 726

Name: ARN 726
Brand: Tocris Bioscience
SKU: 5861

Tocris Bioscience, part of Bio-Techne | Catalog # 5861

COA / SDS

Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe

Discontinued Product

5861 has been discontinued. View all General Laboratory Research Reagent products.

Key Product Details

Description:	Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe
Chemical Name:	4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	268.35

View Full Technical Details for ARN 726

Technical Data
Citations

Biological Activity for ARN 726

ARN 726 is a potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC₅₀ values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.

Technical Data for ARN 726

M. Wt	268.35
Formula	C₁₄H₂₄N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1628343-77-0
PubChem ID	78319072
InChi Key	FNLUJRBWJBUJTC-LBPRGKRZSA-N
Smiles	O=C(OCCCCC1CCCCC1)N[C@H]2CNC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ARN 726

References are publications that support the biological activity of the product.

Romeo Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 2015 PMID: 26102511
Bonezzi An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis. J.Pharmacol.Exp.Ther. 2016 PMID: 26769918
Ribeiro A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation. ACS Chem.Biol. 2015 PMID: 25874594

ARN 726

Tocris Bioscience, part of Bio-Techne | Catalog # 5861

Key Product Details

Biological Activity for ARN 726

Technical Data for ARN 726

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ARN 726

Product Documents for ARN 726

COA

Certificate of Analysis

SDS

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