ARN 14494
Tocris Bioscience, part of Bio-Techne | Catalog # 7134
Potent serine palmitoyltransferase inhibitor
Key Product Details
Description
Potent serine palmitoyltransferase inhibitor
Product Description
ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.Product Specifications
Molecular Weight
424.55
Formula
C24H32N4O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
rel-1-[1-[2-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-carboxamide
CAS Number
1037834-43-7
PubChem ID
24857490
InChI Key
TYZOOEYUTZDYPB-HDICACEKSA-N
SMILES
[H][C@@]12CCC[C@@]1(CN(C(CN3CCC(N4C(CC5=CC(C(NC)=O)=CC=C45)=O)CC3)=O)C2)[H]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.12 | 5 | |
| Ethanol | 21.23 | 50 |
Preparing Stock Solutions
for ARN 14494
The following data is based on the product molecular weight 424.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.71 mL | 23.55 mL | 47.11 mL |
| 2.5 mM | 0.94 mL | 4.71 mL | 9.42 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
| 25 mM | 0.09 mL | 0.47 mL | 0.94 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- De Vita Inhibition of serine palmitoyltransferase by a small organic molecule promotes neuronal survival after astrocyte amyloid beta 1-42 injury. ACS Chem.Neurosci. 2019 PMID: 30481470
Product Specific Notices for ARN 14494
For research use only
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