ARN 11391

Tocris Bioscience, part of Bio-Techne | Catalog # 7909

Potentiator of the IP3-gated calcium channel ITPR1
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Key Product Details

Description

Potentiator of the IP3-gated calcium channel ITPR1

View all IP3 Receptor Modulators »

Product Description

ARN 11391 is a potentiator of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1). It amplifies intracellular calcium ion signaling by acting directly on ITPR1. ARN 11391 also potentiates calcium signaling in cells expressing mutant ITPR1 which is associated with SCA29, a form of spinocerebellar ataxia.

Product Specifications

Molecular Weight

383.49

Formula

C22H29N3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2H-pyran-2-yl)methoxy]phenyl]-2H-indazole-3-carboxamide

CAS Number

1214569-31-9

PubChem ID

46969526

InChI Key

WEHYVOUAIUTKKA-UHFFFAOYSA-N

SMILES

O=C(C1=C2C(CCCC2)=NN1CC)NC3=C(OCC4OCCCC4)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.35 100
Ethanol 38.35 100

Preparing Stock Solutions for ARN 11391

The following data is based on the product molecular weight 383.49

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.30 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ARN 11391

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ARN 11391

For research use only

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