ArMan

Name: ArMan
Brand: Tocris Bioscience
SKU: 8869

Tocris Bioscience, part of Bio-Techne | Catalog # 8869

COA / SDS

DC-SIGN ligand used to target dendritic cells

Key Product Details

Description:	DC-SIGN ligand used to target dendritic cells
Chemical Name:	N-(4-(((2R,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenethyl)pent-4-ynamide
Purity:	≥98% (HPLC)
Molecular Weight:	379.41

View Full Technical Details for ArMan

Technical Data
Citations

Biological Activity for ArMan

ArMan is an aryl mannoside targeting ligand that can be functionalised to the surface of virus like particles (VLPs) via click chemistry. Functionalised particles can be used to target DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin) dendritic cells to promote selective coengagement of DC-SIGN and TLR7, resulting in a Th1-type immune response. In vivo, immunization with VLP-ArMan-OvaI/II significantly inhibits tumor growth in a murine melanoma model.

Technical Data for ArMan

M. Wt	379.41
Formula	C₁₉H₂₅NO₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	170958390
InChi Key	DJVWDLGJYGPTMN-IQRFUGTFSA-N
Smiles	OC[C@@H](O[C@H](OC1=CC=C(C=C1)CCNC(CCC#C)=O)[C@H]2O)[C@@H](O)[C@@H]2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ArMan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.94	100

Preparing Stock Solutions for ArMan

The following data is based on the product molecular weight 379.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.18 mL	26.36 mL
5 mM	0.53 mL	2.64 mL	5.27 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ArMan

References are publications that support the biological activity of the product.

Alam Glycan-modified virus-like particles evoke T helper type 1-like immune responses. ACS Nano 2021 PMID: 32790346
Lensch Carbohydrate-lectin interactions reprogram dendritic cells to promote type 1 anti-tumor immunity. ACS Nano 2024 PMID: 39283240