ARCC 4 negative control
Tocris Bioscience, part of Bio-Techne | Catalog # 7255
Negative control for ARCC 4 (Cat. No. 7254)
Key Product Details
Description
Negative control for ARCC 4 (Cat. No. 7254)
Product Description
ARCC 4 negative control is a negative control for ARCC 4 (Cat. No. 7254). Binds androgen receptors (AR) without inducing degradation.Product Specifications
Molecular Weight
1024.18
Formula
C53H56F3N7O7S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4S)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
2156588-26-8
PubChem ID
145746289
InChI Key
DUPAJELXESPTNF-RNEKHSKBSA-N
SMILES
CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)NC(COCCCCOC4=CC=C(C5=CC=C(N6C(N(C7=CC(C(F)(F)F)=C(C#N)C=C7)C(C6(C)C)=O)=S)C=C5)C=C4)=O)=O)O)=O)SC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 102.42 | 100 |
Preparing Stock Solutions
for ARCC 4 negative control
The following data is based on the product molecular weight 1024.18
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.98 mL | 4.88 mL | 9.76 mL |
| 5 mM | 0.20 mL | 0.98 mL | 1.95 mL |
| 10 mM | 0.10 mL | 0.49 mL | 0.98 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Salami Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun.Biol. 2018 PMID: 30271980
Product Specific Notices for ARCC 4 negative control
For research use only
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