ARC 239 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0928
α2B antagonist
Product Description
ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).Licensing Information
Sold with the permission of Boehringer Ingelheim GmbHProduct Specifications
Molecular Weight
480.43
Formula
C24H29N3O3.2HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
CAS Number
55974-42-0
PubChem ID
10345075
InChI Key
SAJKHRHHDGSJEZ-UHFFFAOYSA-N
SMILES
Cl.Cl.COC1=CC=CC=C1N1CCN(CCN2C(=O)C3=C(C=CC=C3)C(C)(C)C2=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 48.04 | 100 |
Preparing Stock Solutions
for ARC 239 dihydrochloride
The following data is based on the product molecular weight 480.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.41 mL | 20.81 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.16 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fuder and Selback Characterisation of sensory neurotransmission and its inhibition via α2B-adrenoceptors and via non-α2 adrenoceptors in rabbit iris. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 7685502
- Bylund Alpha-2A and alpha-2B adrenergic subtypes: antagonist binding in tissues and cell lines containing only one subtype. J.Pharmacol.Exp.Ther. 1988 PMID: 2835476
Product Specific Notices for ARC 239 dihydrochloride
For research use only
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