APY 29
Tocris Bioscience, part of Bio-Techne | Catalog # 4865
Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
Key Product Details
Description
Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
Product Description
APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.Product Specifications
Molecular Weight
332.36
Formula
C17H16N8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
CAS Number
1216665-49-4
PubChem ID
42627755
InChI Key
WJNBSTLIALIIEW-UHFFFAOYSA-N
SMILES
C1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=CC(C5CC5)=NN4)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 16.62 | 50 | |
| DMSO | 33.24 | 100 |
Preparing Stock Solutions
for APY 29
The following data is based on the product molecular weight 332.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.09 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Korennykh The unfolded protein response signals through high-order assembly of Ire1. Nature 2009 PMID: 19079236
- Wang Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 2012 PMID: 23086298
Product Specific Notices for APY 29
For research use only
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