AP 811
Tocris Bioscience, part of Bio-Techne | Catalog # 5498
High affinity, selective NPR3 antagonist
Key Product Details
Description
High affinity, selective NPR3 antagonist
Product Description
AP 811 is a high affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.Product Specifications
Molecular Weight
915.10
Formula
C46H66N12O8
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
124833-45-0
PubChem ID
44301714
InChI Key
UNMJSSQZDQBGDS-OCFLPWLCSA-N
SMILES
CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- William Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 2008 PMID: 18272821
- Becker Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 2014 PMID: 24353062
- Veale The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 2000 PMID: 10987424
Product Specific Notices for AP 811
For research use only
Loading...
Loading...
Loading...