AP 1903
Tocris Bioscience, part of Bio-Techne | Catalog # 6130
Chemical inducer of protein dimerization; active in vivo
Key Product Details
Description
Chemical inducer of protein dimerization; active in vivo
Product Description
AP 1903 is a chemical protein dimerizer for use in FKBP fusion protein systems. Induces apoptosis in cells expressing a fusion protein consisting of FKBPF36V and intracellular domain of Fas receptor with high potency (EC50 = 0.1 nM). Exhibits >50-fold selectivity for FKBPF36V-Fas fusion protein over wild-type FKBP. Also induces apoptosis in cells expressing Cas9-FK506 fusion proteins, in inducible caspase 9 (iCas9) suicide gene system. Active in vivo.Product Specifications
Molecular Weight
1411.65
Formula
C78H98N4O20
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,2'-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
CAS Number
195514-63-7
PubChem ID
16135625
InChI Key
GQLCLPLEEOUJQC-ZTQDTCGGSA-N
SMILES
O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C4)=O)=O)=CC=C3)CCC8=CC(OC)=C(OC)C=C8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 141.16 | 100 | |
| Ethanol | 141.16 | 100 |
Preparing Stock Solutions
for AP 1903
The following data is based on the product molecular weight 1411.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 5 mM | 0.14 mL | 0.71 mL | 1.42 mL |
| 10 mM | 0.07 mL | 0.35 mL | 0.71 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gargett & Brown The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells. Front.Pharmacol. 2014 PMID: 25389405
- Clackson Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.USA. 1998 PMID: 9724721
Product Specific Notices for AP 1903
For research use only
Loading...
Loading...