AP 18
Tocris Bioscience, part of Bio-Techne | Catalog # 3296
Reversible TRPA1 channel blocker
Product Description
AP 18 is a reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnamaldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).Product Specifications
Molecular Weight
209.67
Formula
C11H12ClNO
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
CAS Number
55224-94-7
PubChem ID
9584673
InChI Key
MHTJEUOFLVQMCL-NJHPPEEMSA-N
SMILES
ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.97 | 100 | |
| Ethanol | 20.97 | 100 |
Preparing Stock Solutions
for AP 18
The following data is based on the product molecular weight 209.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.77 mL | 23.85 mL | 47.69 mL |
| 5 mM | 0.95 mL | 4.77 mL | 9.54 mL |
| 10 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 50 mM | 0.10 mL | 0.48 mL | 0.95 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol.Pain 2009 PMID: 19159452
- Taylor-Clark Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol.Pharmacol. 2009 PMID: 19171673
- Petrus A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 2007 PMID: 18086313
Product Specific Notices for AP 18
For research use only
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