AP 1867 PEG3 Haloalkane New
Tocris Bioscience, part of Bio-Techne | Catalog # 8988
Inducer of proximity between FBKP12 F36V-fused PP2A and haloalkane dehalogenase labeled phosphoproteins (PhosTAC)
Key Product Details
Description
Inducer of proximity between FBKP12 F36V-fused PP2A and haloalkane dehalogenase labeled phosphoproteins (PhosTAC)
Product Description
AP 1867 PEG3 Haloalkane is a heterobifunctional molecule inducing proximity between a Ser/Thr phosphatase (PP2) fused with FKBP12 (F36V) and a phosphosubstrate (PDCD4 and FOXO3a) fused with haloalkane dehalogenase and affecting dephosphorylation of the latter (PhosTAC). In pulldown experiments, AP 1867 PEG3 Haloalkane induces 50% dephosphorylation of PDCD4 at 10μM after 12 h incubation. Targeted protein dephosphorylation with AP 1867 PEG3 Haloalkane can be used to induce dephosphorylation of other haloalkane dehalogenase labeled phosphoproteins.Product Specifications
Molecular Weight
943.57
Formula
C50H71ClN2O13
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[(1R)-1-[3-[2-[2-[2-[2-(6-Chlorohexoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
PubChem ID
166642353
InChI Key
URAXYIMEKGUPKY-WTQYMLSTSA-N
SMILES
O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(NCCOCCOCCOCCCCCCCl)=O)=CC=C3)CCC4=CC(OC)=C(OC)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.18 | 50 | |
| Ethanol | 94.36 | 100 |
Preparing Stock Solutions
for AP 1867 PEG3 Haloalkane
The following data is based on the product molecular weight 943.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.06 mL | 5.30 mL | 10.60 mL |
| 5 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 10 mM | 0.11 mL | 0.53 mL | 1.06 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs) ACS Chem.Biol. 2021 PMID: 34780684
Product Specific Notices for AP 1867 PEG3 Haloalkane
For research use only
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