Ani 9
Tocris Bioscience, part of Bio-Techne | Catalog # 6076
Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
Key Product Details
Description
Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
Product Description
Ani 9 is a potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC50 = 77 nM). Displays no effect on ANO2 activity (at 10 μM). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 μM).Product Specifications
Molecular Weight
332.78
Formula
C17H17ClN2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide
CAS Number
356102-14-2
PubChem ID
9556542
InChI Key
KDALDZRKOBJXIE-VXLYETTFSA-N
SMILES
COC1=C(C=CC=C1)/C=N/NC(COC2=C(C=C(C=C2)Cl)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.28 | 100 |
Preparing Stock Solutions
for Ani 9
The following data is based on the product molecular weight 332.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.00 mL | 15.02 mL | 30.05 mL |
| 5 mM | 0.60 mL | 3.00 mL | 6.01 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.00 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Seo Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 2016 PMID: 27219012
Product Specific Notices for Ani 9
For research use only
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