Anandamide
Tocris Bioscience, part of Bio-Techne | Catalog # 1339
Endogenous and non-selective CB agonist
Key Product Details
Description
Endogenous and non-selective CB agonist
Alternative Names
Arachidonylethanolamide,AEA
Product Description
Anandamide is an endogenous cannabinoid and TRPV1 receptor agonist (Ki values are 89 and 371 nM at CB1 and CB2 receptors respectively; EC50 values are 18, 31 and 27 nM at GPR55, CB1 and CB2 respectively; pKi = 5.68 for rTRPV1). Also blocks TNF-α-induced NF-κB activation via direct inhibition of IKK.Deuterated analog also available.
Product Specifications
Molecular Weight
347.54
Formula
C22H37NO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
CAS Number
94421-68-8
PubChem ID
5281969
InChI Key
LGEQQWMQCRIYKG-DOFZRALJSA-N
SMILES
O=C(NCCO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ellermann Endocannabinoids inhibit the induction of virulence in enteric pathogens. Cell 2020 PMID: 33031742
- Sancho Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway. Mol.Pharmacol. 2003 PMID: 12527815
- Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
- Ross Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br.J.Pharmacol. 2001 PMID: 11159715
- Pertwee Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 1999 PMID: 10469884
- Devane Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992 PMID: 1470919
Product Specific Notices for Anandamide
For research use only
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