Anacardic acid

Product Description

Anacardic acid is a noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC₅₀ values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3 and to inhibit protein SUMOylation. Exhibits antitumor, antimicrobial and antioxidant activity. Also promotes cardiomyocyte differentiation from mESCs.

Solubility

Preparing Stock Solutions for Anacardic acid

The following data is based on the product molecular weight 348.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.35 mL	28.69 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Re Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways. Endocrine 2016 PMID: 26547215
• Fukuda Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 2009 PMID: 19246003
• Balasubramanyam Small molecule modulators of histone acetyltransferase p300. J.Biol.Chem. 2003 PMID: 12624111
• Cui Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eurkaryot.Cell
• Sung Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the Blood 2008 PMID: 18349320
• Kishore Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system. J.Med.Chem. 2008 PMID: 18215015