Amylin
Tocris Bioscience, part of Bio-Techne | Catalog # 3418
Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors
Key Product Details
Description
Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors
Product Description
Amylin is an endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors. Inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. Displays glucose lowering effects in vivo.Product Specifications
Molecular Weight
3903.33
Formula
C165H261N51O55S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
122384-88-7
PubChem ID
16132430
InChI Key
PLOPBXQQPZYQFA-AXPWDRQUSA-N
SMILES
[H]N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 10mg/ml in DMSO |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schmitz Amylin agonists: a novel approach in the treatment of diabetes. Diabetes 2004 PMID: 15561917
- Hoogwerf Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk. Vasc.Health Risk Manag. 2008 PMID: 18561511
- Castillo Amylin/islet polypeptide: biochemistry, physiology, patho-physiology. Diabete Metab. 1995 PMID: 7781840
Product Specific Notices for Amylin
For research use only
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