AMT hydrochloride

Name: AMT hydrochloride
Brand: Tocris Bioscience
SKU: 0871

Tocris Bioscience, part of Bio-Techne | Catalog # 0871

Citations (2)

COA / SDS

Potent, selective iNOS inhibitor

Key Product Details

Description:	Potent, selective iNOS inhibitor
Chemical Name:	2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
Molecular Weight:	166.67

View Full Technical Details for AMT hydrochloride

Technical Data
Citations

Biological Activity for AMT hydrochloride

AMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC₅₀ = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

Technical Data for AMT hydrochloride

M. Wt	166.67
Formula	C₅H₁₀N₂S.HCl
Storage	Desiccate at +4°C
CAS Number	21463-31-0
PubChem ID	2733501
InChi Key	HVJCRMIQAMEJNM-UHFFFAOYSA-N
Smiles	NC1=NCCC(S1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMT hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		10

Preparing Stock Solutions for AMT hydrochloride

The following data is based on the product molecular weight 166.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	60.00 mL	299.99 mL	599.99 mL
0.5 mM	12.00 mL	60.00 mL	120.00 mL
1 mM	6.00 mL	30.00 mL	60.00 mL
5 mM	1.20 mL	6.00 mL	12.00 mL

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References for AMT hydrochloride

References are publications that support the biological activity of the product.

Nakane Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 1995 PMID: 7536889
Yu Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 2005 PMID: 15845578
Liao Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 2006 PMID: 16877524