Amiodarone hydrochloride

Name: Amiodarone hydrochloride
Brand: Tocris Bioscience
SKU: 4095

Tocris Bioscience, part of Bio-Techne | Catalog # 4095

Citations (2)

COA / SDS

Broad spectrum ion channel blocker; antiarrhythmic

Discontinued Product

4095 has been discontinued. View all Ion Channel Modulators products.

Key Product Details

Description:	Broad spectrum ion channel blocker; antiarrhythmic
Chemical Name:	2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	681.77

View Full Technical Details for Amiodarone hydrochloride

Technical Data
Citations

Biological Activity for Amiodarone hydrochloride

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late I_Na, I_Ca, I_Kr and I_Ks and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca²⁺ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

Technical Data for Amiodarone hydrochloride

M. Wt	681.77
Formula	C₂₅H₂₉I₂NO₃.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	19774-82-4
PubChem ID	29770
InChi Key	ITPDYQOUSLNIHG-UHFFFAOYSA-N
Smiles	CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Amiodarone hydrochloride

References are publications that support the biological activity of the product.

Payne Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. EBioMedicine 2021 PMID: 34933180
Han Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not DA neurons. PLoS One. 2009 PMID: 19774075
di Matola Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 2000 PMID: 11095475
Balgi Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 2009 PMID: 19771169
Antzelevitch Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 2004 PMID: 15302796

Product Documents for Amiodarone hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Amiodarone hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov