AMG 517

Tocris Bioscience, part of Bio-Techne | Catalog # 5995

Potent TRPV1 antagonist
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Key Product Details

Description

Potent TRPV1 antagonist

View all TRPV Antagonists »

Product Description

AMG 517 is a potent TRPV1 antagonist (IC50 = 0.9 nM). Inhibits capsaican-induced flinching and reverses analgesia in an inflammatory pain model in rats. Orally bioavailable.

Product Specifications

Molecular Weight

430.41

Formula

C20H13F3N4O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide

CAS Number

659730-32-2

PubChem ID

16007367

InChI Key

YUTIXVXZQIQWGY-UHFFFAOYSA-N

SMILES

O=C(NC(S1)=NC(C1=CC=C2)=C2OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.3 10

Preparing Stock Solutions for AMG 517

The following data is based on the product molecular weight 430.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.23 mL 116.17 mL 232.34 mL
0.5 mM 4.65 mL 23.23 mL 46.47 mL
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL

Calculators

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Reconstitution Calculator

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Product Documents for AMG 517

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMG 517

For research use only

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