AMG 333
Tocris Bioscience, part of Bio-Techne | Catalog # 6874
Potent and selective TRPM8 antagonist; active in vivo
Key Product Details
Description
Potent and selective TRPM8 antagonist; active in vivo
Product Description
AMG 333 is a potent and selective TRPM8 antagonist (IC50 values are 13 and 20 nM for hTRPM8 and rTRPM8, respectively). Displays high selectivity over other TRP channels (IC50 >20 μM, TRPV1/V3/V4/A1). Inhibits icilin-induced wet-dog shake in rats and suppresses cold-induced increases in blood pressure in the rat cold-pressor test.Product Specifications
Molecular Weight
453.33
Formula
C20H12F5N3O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-[[[(S)-(3-Fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid
CAS Number
1416799-28-4
PubChem ID
71144018
InChI Key
QEBYISWYMFIXOZ-INIZCTEOSA-N
SMILES
OC(=O)C1=CC=C(N=C1)C(=O)N[C@@H](C1=CC(F)=C(OC(F)(F)F)C=C1)C1=C(F)C=CC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.33 | 100 | |
| Ethanol | 45.33 | 100 |
Preparing Stock Solutions
for AMG 333
The following data is based on the product molecular weight 453.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.03 mL | 22.06 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for AMG 333
For research use only
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