AMG 18 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6166
Potent and selective IRE1α inhibitor
Product Description
AMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.Product Specifications
Molecular Weight
637.58
Formula
C31H29ClN6O3S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
CAS Number
2250019-92-0
PubChem ID
134160238
InChI Key
CNWIPRHGMZTPSB-BOXHHOBZSA-N
SMILES
CC1=C(C2=C(C(NS(=O)(C3=C(C=CC=C3)Cl)=O)=CC=C2)C=C1)OC4=C(C5=NC(N[C@H]6CCCNC6)=NC=C5)C=CC=N4.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 63.76 | 100 | |
| DMSO | 63.76 | 100 |
Preparing Stock Solutions
for AMG 18 hydrochloride
The following data is based on the product molecular weight 637.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.57 mL | 7.84 mL | 15.68 mL |
| 5 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 10 mM | 0.16 mL | 0.78 mL | 1.57 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Harrington Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 2014 PMID: 25589933
Product Specific Notices for AMG 18 hydrochloride
For research use only
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