AMD 3465 hexahydrobromide

Tocris Bioscience, part of Bio-Techne | Catalog # 4179

Potent and selective CXCR4 antagonist
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Key Product Details

Description

Potent and selective CXCR4 antagonist

View all Chemokine CXC Receptor Antagonists »

Product Description

AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

Product Specifications

Molecular Weight

896.07

Formula

C24H38N6.6HBr

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

CAS Number

185991-07-5

PubChem ID

9897616

InChI Key

ARHBIBDGWDRBJH-UHFFFAOYSA-N

SMILES

C1(CN3CCCNCCNCCCNCC3)=CC=C(CNCC2=NC=CC=C2)C=C1.Br.Br.Br.Br.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.8 50
DMSO 22.4 25

Preparing Stock Solutions for AMD 3465 hexahydrobromide

The following data is based on the product molecular weight 896.07

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.23 mL 11.16 mL 22.32 mL
2.5 mM 0.45 mL 2.23 mL 4.46 mL
5 mM 0.22 mL 1.12 mL 2.23 mL
25 mM 0.04 mL 0.22 mL 0.45 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AMD 3465 hexahydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMD 3465 hexahydrobromide

For research use only

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