AM 4113

Tocris Bioscience, part of Bio-Techne | Catalog # 6193

COA / SDS

High affinity and selective CB1 antagonist

Key Product Details

Description:	High affinity and selective CB₁ antagonist
Chemical Name:	5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	380.66

View Full Technical Details for AM 4113

Technical Data
Citations

Biological Activity for AM 4113

AM 4113 is a high affinity and selective CB₁ antagonist (K_d = 0.89 nM). Exhibits 100-fold selectivity for CB₁ over CB₂. Attenuates CB₁ agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.

Compound Libraries for AM 4113

AM 4113 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AM 4113

M. Wt	380.66
Formula	C₁₇H₁₂Cl₃N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	614726-85-1
PubChem ID	66844170
InChi Key	BBUKVPCUOHFAQN-UHFFFAOYSA-N
Smiles	CC1=C(C2=CC=C(C=C2)Cl)N(C3=C(C=C(C=C3)Cl)Cl)N=C1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AM 4113

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.61	20
	ethanol	7.61	20

Preparing Stock Solutions for AM 4113

The following data is based on the product molecular weight 380.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.14 mL	65.68 mL	131.35 mL
1 mM	2.63 mL	13.14 mL	26.27 mL
2 mM	1.31 mL	6.57 mL	13.14 mL
10 mM	0.26 mL	1.31 mL	2.63 mL

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References for AM 4113

References are publications that support the biological activity of the product.

Hodge The cannabinoid CB₁ receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats Behav. Brain Res. 2008 PMID: 18602425
Sink The novel cannabinoid CB₁ receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 2008 PMID: 17581535