AM 281

Tocris Bioscience, part of Bio-Techne | Catalog # 1115

Potent and selective CB1 inverse agonist
Discontinued Product
1115 has been discontinued. View all Cannabinoid R1/CB1 Inverse Agonists products.

Key Product Details

Description

Potent and selective CB1 inverse agonist

View all Cannabinoid R1/CB1 Inverse Agonists »

Product Description

AM 281 is a potent, selective CB1 cannabinoid receptor antagonist/inverse agonist (Ki values are 12 and 4200 nM for CB1 and CB2 receptors respectively). Increases locomotor activity following systemic administration in vivo. Analog of SR141716A (Ki = 14 nM).

Licensing Information

Sold with the permission of the University of Connecticut

Product Specifications

Molecular Weight

557.22

Formula

C21H19Cl2IN4O2

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide

CAS Number

202463-68-1

PubChem ID

4302962

InChI Key

AJFFBPZYXRNAIC-UHFFFAOYSA-N

SMILES

CC1=C(N(N=C1C(=O)NN1CCOCC1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(I)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.79 75 with gentle warming

Preparing Stock Solutions for AM 281

The following data is based on the product molecular weight 557.22

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.39 mL 11.96 mL 23.93 mL
3.75 mM 0.48 mL 2.39 mL 4.79 mL
7.5 mM 0.24 mL 1.20 mL 2.39 mL
37.5 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Reconstitution Calculator

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Product Documents for AM 281

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AM 281

For research use only

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