Allopregnanolone

Name: Allopregnanolone
Brand: Tocris Bioscience
SKU: 3653

Tocris Bioscience, part of Bio-Techne | Catalog # 3653

Citations (44)

COA / SDS

Positive allosteric modulator of GABAA receptors

Key Product Details

Description:	Positive allosteric modulator of GABA_A receptors
Alternative Names:	3a,5a-THPROG
Chemical Name:	(3α,5α)-3-Hydroxy-pregnan-20-one
Molecular Weight:	318.49

View Full Technical Details for Allopregnanolone

Technical Data
Citations

Biological Activity for Allopregnanolone

Allopregnanolone is a GABA_A receptor positive allosteric modulator. Neuroactive steroid.

Technical Data for Allopregnanolone

M. Wt	318.49
Formula	C₂₁H₃₄O₂
Storage	Store at RT
CAS Number	516-54-1
PubChem ID	92786
InChi Key	AURFZBICLPNKBZ-SYBPFIFISA-N
Smiles	C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Allopregnanolone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.85	100
	ethanol	31.85	100

Preparing Stock Solutions for Allopregnanolone

The following data is based on the product molecular weight 318.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.14 mL	15.70 mL	31.40 mL
5 mM	0.63 mL	3.14 mL	6.28 mL
10 mM	0.31 mL	1.57 mL	3.14 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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Reconstitution Calculator

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References for Allopregnanolone

References are publications that support the biological activity of the product.

Belelli and Lambert Neurosteroids: endogenous regulators of the GABA_A receptor. Nat.Rev.Neurosci. 2005 PMID: 15959466
Agis-Balboa Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA
Puia Neurosteroids act on recombinant human GABA_A receptors. Neuron 1990 PMID: 2160838