AKOS 022

Name: AKOS 022
Brand: Tocris Bioscience
SKU: 7135

Tocris Bioscience, part of Bio-Techne | Catalog # 7135

COA / SDS

Voltage-dependent anion channel (VDAC) inhibitor

Key Product Details

Description:	Voltage-dependent anion channel (VDAC) inhibitor
Chemical Name:	1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	467.87

View Full Technical Details for AKOS 022

Technical Data
Citations

Biological Activity for AKOS 022

AKOS 022 is a voltage-dependent anion channel (VDAC; K_d = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC₅₀ values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.

Compound Libraries for AKOS 022

AKOS 022 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AKOS 022

M. Wt	467.87
Formula	C₂₂H₂₁ClF₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	878983-38-1
PubChem ID	5304523
InChi Key	ZZVCWIMICOFQNJ-UHFFFAOYSA-N
Smiles	FC(F)(OC1=CC=C(C=C1)NC2CCN(C3CC(N(C4=CC=C(C=C4)Cl)C3=O)=O)CC2)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AKOS 022

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.79	100

Preparing Stock Solutions for AKOS 022

The following data is based on the product molecular weight 467.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.14 mL	10.69 mL	21.37 mL
5 mM	0.43 mL	2.14 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.14 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for AKOS 022

References are publications that support the biological activity of the product.

Zhang Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells. Cell Metab. 2019 PMID: 30293774
Ben-Hail Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction. J.Biol.Chem. 2016 PMID: 27738100