AK 7
Tocris Bioscience, part of Bio-Techne | Catalog # 4754
Selective SIRT2 inhibitor; brain penetrant
Key Product Details
Description
Selective SIRT2 inhibitor; brain penetrant
Product Description
AK 7 is a selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.Product Specifications
Molecular Weight
437.35
Formula
C19H21BrN2O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
CAS Number
420831-40-9
PubChem ID
1328033
InChI Key
IYAYHZZWYNXHEQ-UHFFFAOYSA-N
SMILES
O=C(NC2=CC(Br)=CC=C2)C1=CC(S(N3CCCCCC3)(=O)=O)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.73 | 100 |
Preparing Stock Solutions
for AK 7
The following data is based on the product molecular weight 437.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.43 mL | 22.86 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Taylor A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 2011 PMID: 21370928
- Chopra The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 PMID: 23200855
Product Specific Notices for AK 7
For research use only
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