AIM 100

Tocris Bioscience, part of Bio-Techne | Catalog # 4946

Potent and selective Ack1 (TNK2) inhibitor
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Key Product Details

Description

Potent and selective Ack1 (TNK2) inhibitor

View all Ack1 Inhibitors »

Product Description

AIM 100 is a potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice. Also promotes DAT endocytosis and oligomerization.

Product Specifications

Molecular Weight

371.43

Formula

C23H21N3O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine

CAS Number

873305-35-2

PubChem ID

11501591

InChI Key

XNFHHOXCDUAYSR-SFHVURJKSA-N

SMILES

C1(C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)=C3N=CN=C1NC[C@H]2OCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.14 100
Ethanol 37.14 100

Preparing Stock Solutions for AIM 100

The following data is based on the product molecular weight 371.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AIM 100

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AIM 100

For research use only

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