AF 64394
Tocris Bioscience, part of Bio-Techne | Catalog # 6931
Potent and selective GPR3 inverse agonist
Key Product Details
Description
Potent and selective GPR3 inverse agonist
Product Description
AF 64394 is a potent and selective GPR3 inverse agonist (pIC50 = 7.3). Selective for GPR3 over GPR6 and GPR12 (pIC50 values are 5.1 and 4.9, respectively).Product Specifications
Molecular Weight
393.87
Formula
C21H20ClN5O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
CAS Number
1637300-25-4
PubChem ID
125286314
InChI Key
WBYNZQXAAWPAGR-UHFFFAOYSA-N
SMILES
CC(C)OC1=C(CNC2=CC(=NC3=NC=NN23)C2=CC=CC=C2)C=CC(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.39 | 100 |
Preparing Stock Solutions
for AF 64394
The following data is based on the product molecular weight 393.87
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.69 mL | 25.39 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Godlewski Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue. Sci.Rep. 2015 PMID: 26455425
- Jensen The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg.Med.Chem.Lett. 2014 PMID: 25442311
Product Specific Notices for AF 64394
For research use only
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