AEBSF

Name: AEBSF
Brand: Tocris Bioscience
SKU: 5175

Tocris Bioscience, part of Bio-Techne | Catalog # 5175

Citations (17)

COA / SDS

Broad spectrum, irreversible inhibitor of serine proteases

Key Product Details

Description:	Broad spectrum, irreversible inhibitor of serine proteases
Chemical Name:	4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	239.69

View Full Technical Details for AEBSF

Technical Data
Citations

Biological Activity for AEBSF

AEBSF is a broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy.

Compound Libraries for AEBSF

AEBSF is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AEBSF

M. Wt	239.69
Formula	C₈H₁₀FNO₂S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	30827-99-7
PubChem ID	186136
InChi Key	WRDABNWSWOHGMS-UHFFFAOYSA-N
Smiles	NCCC1=CC=C(S(=O)(F)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AEBSF

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.97	100
	DMSO	23.97	100

Preparing Stock Solutions for AEBSF

The following data is based on the product molecular weight 239.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.17 mL	20.86 mL	41.72 mL
5 mM	0.83 mL	4.17 mL	8.34 mL
10 mM	0.42 mL	2.09 mL	4.17 mL
50 mM	0.08 mL	0.42 mL	0.83 mL

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Reconstitution Calculator

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References for AEBSF

References are publications that support the biological activity of the product.

Saw Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS ONE 2012 PMID: 22829914
Diatchuk Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J.Biol.Chem. 1997 PMID: 9148950