ACT 462206

Name: ACT 462206
Brand: Tocris Bioscience
SKU: 5319

Tocris Bioscience, part of Bio-Techne | Catalog # 5319

Citations (4)

COA / SDS

Potent, dual orexin receptor antagonist

Key Product Details

Description:	Potent, dual orexin receptor antagonist
Chemical Name:	(2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	388.48

View Full Technical Details for ACT 462206

Technical Data
Citations

Biological Activity for ACT 462206

ACT 462206 is a potent, dual orexin receptor antagonist (IC₅₀ values are 11 and 60 nM for OX₂ and OX₁ receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

Compound Libraries for ACT 462206

ACT 462206 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ACT 462206

M. Wt	388.48
Formula	C₂₀H₂₄N₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1361321-96-1
PubChem ID	40924317
InChi Key	NHPQGZOBHSVTAQ-IBGZPJMESA-N
Smiles	CC1=CC(NC([C@@H]2CCCN2S(C3=CC=C(OC)C=C3)(=O)=O)=O)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ACT 462206

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.85	100
	ethanol	38.85	100

Preparing Stock Solutions for ACT 462206

The following data is based on the product molecular weight 388.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.87 mL	25.74 mL
5 mM	0.51 mL	2.57 mL	5.15 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Reconstitution Calculator

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References for ACT 462206

References are publications that support the biological activity of the product.

Boss Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 2014 PMID: 25147058