ACT 462206

Tocris Bioscience, part of Bio-Techne | Catalog # 5319

Potent, dual orexin receptor antagonist
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Key Product Details

Description

Potent, dual orexin receptor antagonist

View all Orexin Receptor Antagonists »

Product Description

ACT 462206 is a potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

Product Specifications

Molecular Weight

388.48

Formula

C20H24N2O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide

CAS Number

1361321-96-1

PubChem ID

40924317

InChI Key

NHPQGZOBHSVTAQ-IBGZPJMESA-N

SMILES

CC1=CC(NC([C@@H]2CCCN2S(C3=CC=C(OC)C=C3)(=O)=O)=O)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.85 100
Ethanol 38.85 100

Preparing Stock Solutions for ACT 462206

The following data is based on the product molecular weight 388.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.87 mL 25.74 mL
5 mM 0.51 mL 2.57 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for ACT 462206

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ACT 462206

For research use only

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