ACT 335827

Name: ACT 335827
Brand: Tocris Bioscience
SKU: 4983

Tocris Bioscience, part of Bio-Techne | Catalog # 4983

Citations (2)

COA / SDS

Potent and selective OX1 antagonist

Key Product Details

Description:	Potent and selective OX₁ antagonist
Chemical Name:	(aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	518.64

View Full Technical Details for ACT 335827

Technical Data
Citations

Biological Activity for ACT 335827

ACT 335827 is a potent and selective orexin OX₁ receptor antagonist (K_b values are 41 and 560 nM for OX₁ and OX₂ receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.

Technical Data for ACT 335827

M. Wt	518.64
Formula	C₃₁H₃₈N₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1354039-86-3
PubChem ID	54765113
InChi Key	HXHOBPVRRPCTLG-SETSBSEESA-N
Smiles	O=C(NC(C)C)[C@@H]([C@]4=CC=CC=C4)N2CCC1=CC(OC)=C(OC)C=C1[C@@H]2CC3=CC(OC)=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ACT 335827

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.86	100
	ethanol	51.86	100

Preparing Stock Solutions for ACT 335827

The following data is based on the product molecular weight 518.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.64 mL	19.28 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
10 mM	0.19 mL	0.96 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for ACT 335827

References are publications that support the biological activity of the product.

Steiner Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 2013 PMID: 23589487